Montbretin A

Montbretin A is an acylated flavonol glycoside that has been found in C. crocosmiiflora and has antidiabetic activity. It inhibits human pancreatic alpha-amylase and B. fibrisolvens amylase B (Kis = 8.1 and 1,600 nM, respectively). Montbretin A reduces blood glucose levels in Zucker diabetic fatty rats when administered at a dose of 7.4 mg/kg per day.Formal Name: 2-[4-[[4-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-xylopyranosyl]oxy]-3,5-dihydroxyphenyl]-3-[[O-beta-D-glucopyranosyl-(1->2)-O-6-O-[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]-beta-D-glucopyranosyl-(1->2)-6-deoxy-alpha-L-mannopyranosyl]oxy]-5,7-dihydroxy-4H-1-benzopyran-4-one. CAS Number: 115712-92-0. Synonyms: MbA. Molecular Formula: C53H64O33. Formula Weight: 1229.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 2 mg/ml, Ethanol: insol, PBS (pH 7.2): 2 mg/ml. lambdamax: 267, 329 nm. SMILES: C[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@H](O[C@@H]2CO[C@@H](OC3=C(O)C=C(C4=C(O[C@H]5[C@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O7)[C@@H](O)[C@H](O)[C@@H](COC(/C=C/C8=CC(O)=C(O)C=C8)=O)O6)[C@H](O)[C@@H](O)[C@H](C)O5)C(C9=C(O)C=C(O)C=C9O4)=O)C=C3O)[C@H](O)[C@H]2O)O1. InChi Code: InChI=1S/C53H64O33/c1-15-31(62)37(68)42(73)50(77-15)81-28-14-76-49(41(72)35(28)66)83-45-23(59)8-18(9-24(45)60)44-46(36(67)30-22(58)10-19(55)11-25(30)79-44)84-52-47(39(70)32(63)16(2)78-52)86-53-48(85-51-43(74)38(69)33(64)26(12-54)80-51)40(71)34(65)27(82-53)13-75-29(61)6-4-17-3-5-20(56)21(57)7-17/h3-11,15-16,26-28,31-35,37-43,47-60,62-66,68-74H,12-14H2,1-2H3/b6-4+/t15-,16-,26+,27+,28+,31-,32-,33+,34+,35-,37+,38-,39+,40-,41+,42+,43+,47+,48+,49-,50-,51-,52-,53-/m0/s1. InChi Key: FHVDXUPJFGRQLV-OWPXYNISSA-N.