Mogroside IIIE

Mogroside IIIE is a cucurbitane glycoside that has been found in S. grosvenorii and has anti-inflammatory activity. It inhibits LPS-induced secretion of IL-1beta, IL-6, and Tnf-alpha from, as well as LPS-induced increases in toll-like receptor 4 (TLR4) levels in, RAW 264.7 macrophages when used at a concentration of 50 µM. Mogroside IIIE (20 mg/kg) increases in bronchoalveolar lavage fluid (BALF) levels of IL-1beta, IL-6, and TNF-alpha, and increases in lung tissue myeloperoxidase (MPO) activity in a mouse model of LPS-induced acute lung injury. It decreases lung fibrosis, as well as increases animal survival and reduces lung levels of matrix metalloproteinase-9 (MMP-9), in a mouse model of pulmonary fibrosis induced by the glycopeptide bleomycin (Cay-13877) when administered at a dose of 20 mg/kg per day. Formulations containing mogroside IIIE have been used as sweeteners in food products.Formal Name: (3beta,9beta,10alpha,11alpha,24R )-3-(beta-D-glucopyranosyloxy)-11,25-dihydroxy-9-methyl-19-norlanost-5-en-24-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside. CAS Number: 88901-37-5. Synonyms: MGIIIE. Molecular Formula: C48H82O19. Formula Weight: 963.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble, Methanol: Slightly soluble. SMILES: C[C@]12[C@](CC=C3[C@@]2([H])CC[C@@H](C3(C)C)O[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O)([H])[C@]5([C@](C[C@H]1O)([C@]([C@@H](CC[C@H](C(O)(C)C)O[C@H]6[C@H](O[C@@H]7O[C@H](CO)[C@@H](O)[C@H](O)[C@H]7O)[C@@H](O)[C@H](O)[C@@H](CO)O6)C)([H])CC5)C)C. InChi Code: InChI=1S/C48H82O19/c1-21(9-13-31(45(4,5)61)66-43-40(37(58)34(55)27(20-51)64-43)67-42-39(60)36(57)33(54)26(19-50)63-42)22-15-16-46(6)28-12-10-23-24(48(28,8)29(52)17-47(22,46)7)11-14-30(44(23,2)3)65-41-38(59)35(56)32(53)25(18-49)62-41/h10,21-22,24-43,49-61H,9,11-20H2,1-8H3/t21-,22-,24-,25-,26-,27-,28+,29-,30+,31-,32-,33-,34-,35+,36+,37+,38-,39-,40-,41+,42+,43+,46+,47-,48+/m1/s1. InChi Key: QATISCJMIITVAB-CNEPTXDISA-N. Origin: Plant/Siraitia grosvenorii (Swingle).