Lipid S4 (hydrochloride)

An ionizable cationic lipid for LNP brain targeting, has been used in the generation of LNPs for the delivery of mRNA in vitro and in vivo, contains the 5-HT3 ligand SR-527227, which allows lipid S4-based LNPs to be targeted to the brain, lipid S4 LNPs containing lipid S4 and encapsulating mRNA encoding GFP accumulate primarily in neurons, astrocytes, microglia, and BCECs in mice, lipid S4-containing LNPs encapsulating mRNA encoding a modified form of IL-12 reduce tumor growth and increase survival in an orthotopic mouse model of glioblastoma. SMILES: ClC1=CC=CC(N2CCC(NC(CCCCCN(CCCCCCCCC(OC(CC)CCCCC)=O)CCCCCCCCC(OC(CC)CCCCC)=O)=O)CC2)=N1.Cl. InChi Code: InChI=1S/C50H89ClN4O5.ClH/c1-5-9-20-29-44(7-3)59-49(57)34-23-15-11-13-17-25-38-54(39-26-18-14-12-16-24-35-50(58)60-45(8-4)30-21-10-6-2)40-27-19-22-33-48(56)52-43-36-41-55(42-37-43)47-32-28-31-46(51)53-47,/h28,31-32,43-45H,5-27,29-30,33-42H2,1-4H3,(H,52,56),1H. InChi Key: BEQPSSOATPCHEX-UHFFFAOYSA-N