Lipid ND-O1

Item number	Size	Manual	Delivery time	Price
Cay43010-1	1 mg	-	6 - 10 business days*	88.00€
Cay43010-5	5 mg	-	6 - 10 business days*	351.00€
Cay43010-10	10 mg	-	6 - 10 business days*	658.00€

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Lipid ND-O1 is an ether-containing ionizable cationic lipid (pKa = 6.6) that has been used in the... more

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Product information "Lipid ND-O1"

Lipid ND-O1 is an ether-containing ionizable cationic lipid (pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo. LNPs containing ND-O1 and encapsulating Cy5-labeled siRNA selectively accumulate in the liver over the spleen, heart, kidney, and lung in mice. LNPs containing ND-O1 and encapsulating siRNA targeting heat shock protein 47 (Hsp47) decrease hepatic collagen, TNF-alpha, IL-1beta, TGF-beta, and IL-6 levels in a mouse model of hepatic fibrosis induced by carbon tetrachloride (CCL4). InChI: InChI=1S/C43H85NO6/c1-4-7-10-13-17-23-30-41(31-24-18-14-11-8-5-2)50-43(47)33-26-20-16-22-28-35-44(36-37-45)34-27-21-15-19-25-32-42(46)49-40-39-48-38-29-12-9-6-3/h41,45H,4-40H2,1-3H3 InChIKey: AJCULPGBAFPOED-UHFFFAOYSA-N SMILES: O=C(OC(CCCCCCCC)CCCCCCCC)CCCCCCCN(CCCCCCCC(OCCOCCCCCC)=O)CCO

Keywords:	SM-86 Analog-2, heptadecan-9-yl 8-((8-(2-(hexyloxy)ethoxy)-8-oxooctyl)(2-hydroxyethyl)amino)octanoate
Supplier:	Cayman Chemical
Supplier-Nr:	43010

Properties

Application:	Ether-containing ionizable cationic lipid, LNP generation
MW:	712.15 D
Formula:	C43H85NO6
Purity:	>90%
Format:	Solution

Database Information

Handling & Safety

Storage:	-20°C
Shipping:	+20°C (International: -20°C)
Signal Word:	Warning
GHS Hazard Pictograms:
H Phrases:	H302, H400, H410
P Phrases:	P264, P270, P273, P301+310, P330, P391, P501