Lipid HTO12

Lipid HTO12 is an ionizable cationic lipid (pKa = 6.432) that has been used in combination with other lipids in the formation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102 (Cay-33474).Formal Name: heptadecan-9-yl 8-((2-hydroxyethyl)(2-hydroxytetradecyl)amino)octanoate. Molecular Formula: C41H83NO4. Formula Weight: 654.1. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: OCCN(CC(O)CCCCCCCCCCCC)CCCCCCCC(OC(CCCCCCCC)CCCCCCCC)=O. InChi Code: InChI=1S/C41H83NO4/c1-4-7-10-13-16-17-18-19-21-26-31-39(44)38-42(36-37-43)35-30-25-20-24-29-34-41(45)46-40(32-27-22-14-11-8-5-2)33-28-23-15-12-9-6-3/h39-40,43-44H,4-38H2,1-3H3. InChi Key: AXNSKPOIXOXYSH-UHFFFAOYSA-N.