Lipid C16-C

Lipid C16-C is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing lipid C16-C selectively traffic to mouse liver and spleen over the lungs, kidneys, lymph nodes, and heart. LNPs containing lipid C16-C and encapsulating mRNA encoding HER2-targeting chimeric antigen receptor (CAR) induce CAR expression in human macrophages ex vivo and induce cytotoxicity in HER2-expressing SKOV3 ovarian cancer cells in vitro. InChI: InChI=1S/C98H201N5O9/c1-6-11-16-21-26-31-36-41-46-51-56-61-66-94(104)89-101(78-82-110-86-88-112-84-80-103(92-97(107)69-64-59-54-49-44-39-34-29-24-19-14-9-4)93-98(108)70-65-60-55-50-45-40-35-30-25-20-15-10-5)76-75-99-71-73-100(74-72-99)77-81-109-85-87-111-83-79-102(90-95(105)67-62-57-52-47-42-37-32-27-22-17-12-7-2)91-96(106)68-63-58-53-48-43-38-33-28-23-18-13-8-3/h94-98,104-108H,6-93H2,1-5H3, InChIKey: AFXLHIXDLDFTAT-UHFFFAOYSA-N, SMILES: OC(CN(CCOCCOCCN(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O)CCN1CCN(CC1)CCOCCOCCN(CC(CCCCCCCCCCCCCC)O)CC(CCCCCCCCCCCCCC)O)CCCCCCCCCCCCCC