Lipid 14

Lipid 14 is an ionizable cationic amino lipid that has been used in the formation of lipid nanoparticles (LNPs). LNPs containing lipid 14 and encapsulating mRNA encoding severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein receptor-binding domain (RBD), also known as the surface glycoprotein RBD, increase anti-RBD antibody levels in mice, as well as increase the number of isolated mouse splenocytes secreting IFN-gamma and IL-2, but not IL-4 or IL-10, when incubated with the SARS-CoV-2 spike glycoprotein. LNPs containing lipid 14 and encapsulating mRNA encoding the bacterial Caf1 (F1) capsule antigen from Y. pestis, the bacteria that causes bubonic plague, induces anti-F1 cellular and humoral responses and protects against lethal Y. pestis infection in mice.Formal Name: ((2-((4-(dimethylamino)butanoyl)oxy)ethyl)azanediyl)bis(octane-8,1-diyl) bis(2-hexyldecanoate). CAS Number: 2430034-05-0. Molecular Formula: C56H110N2O6. Formula Weight: 907.5. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Ethanol: Soluble, Methyl Acetate: 25 mg/mL. SMILES: O=C(OCCCCCCCCN(CCOC(CCCN(C)C)=O)CCCCCCCCOC(C(CCCCCC)CCCCCCCC)=O)C(CCCCCC)CCCCCCCC. InChi Code: InChI=1S/C56H110N2O6/c1-7-11-15-19-25-33-42-52(40-31-17-13-9-3)55(60)63-49-37-29-23-21-27-35-46-58(48-51-62-54(59)44-39-45-57(5)6)47-36-28-22-24-30-38-50-64-56(61)53(41-32-18-14-10-4)43-34-26-20-16-12-8-2/h52-53H,7-51H2,1-6H3. InChi Key: NGUVKPMCPAGUDU-UHFFFAOYSA-N.