(±)-Linalool-d3

(±)-Linalool-d3 is intended for use as an internal standard for the quantification of (±)-linalool (Cay-21575) by GC- or LC-MS. (±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities. It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively. (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 µM, respectively). It induces recruitment of a PGC-1alpha coactivator peptide to the PPARalpha ligand binding domain (EC50 = 5.45 µM in a TR-FRET assay). In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARalpha-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schistosomulum recovered from mouse skin after S. japonicium challenge infection. (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils, as well as the production of TNF-alpha, IL-6, IL-1beta, IL-8, and MCP-1, in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation. It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.Formal Name: 3,7-dimethyl-1,6-octadien-1,1,2-d3-3-ol. CAS Number: 1216673-02-7. Synonyms: dl-Linalool-d3. Molecular Formula: C10H15D3O. Formula Weight: 157.3. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A neat oil. Solubility: Chloroform: Slightly soluble, Ethyl Acetate: Slightly soluble, Methanol: Slightly soluble. SMILES: C/C(C)=C/CCC(O)(C)/C([2H])=C([2H])/[2H]. InChi Code: InChI=1S/C10H18O/c1-5-10(4,11)8-6-7-9(2)3/h5,7,11H,1,6,8H2,2-4H3/i1D2,5D. InChi Key: CDOSHBSSFJOMGT-WSWICNJZSA-N. Origin: Synthetic.