Leukotriene C4 methyl ester

Leukotriene C4 methyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10007164-25 25 µg -

6 - 10 business days*

Cay10007164-50 50 µg -

6 - 10 business days*

Cay10007164-100 100 µg -

6 - 10 business days*

Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed... more
Product information "Leukotriene C4 methyl ester"
Leukotriene C4 (LTC4) is the parent cysteinyl-leukotriene produced by the LTC4 synthase-catalyzed conjugation of glutathione to LTA4. LTC4 is produced by neutrophils, macrophages, and mast cells, and by transcellular metabolism in platelets. It is one of the constituents of slow-reacting substance of anaphylaxis (SRS-A) and exhibits potent smooth muscle contracting activity. LTC4-induced bronchoconstriction and enhanced vascular permeability contribute to the pathogenesis of asthma and acute allergic hypersensitivity. The concentration of LTC4 required to produce marked contractions of lung parenchymal strips and isolated tracheal rings is about 1 nM. LTC4 methyl ester is a more lipid soluble form of LTC4. The biological activity of LTC4 methyl ester has not been reported. Formal Name: 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester. CAS Number: 73958-10-8. Synonyms: LTC4 methyl ester. Molecular Formula: C31H49N3O9S. Formula Weight: 639.8. Purity: >97%. Formulation: A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 50 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): .15 mg/ml. lambdamax: 280 nm. SMILES: CCCCC/C=C\C\C=C/C=C\C=C/C(SCC(N)(C(=O)NCC(=O)O)N1C(=O)CCC1C(=O)O)[C@@H](O)CCCC(=O)OC. InChi Code: InChI=1S/C31H49N3O9S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-26(25(35)16-15-18-29(39)43-2)44-22-24(30(40)33-21-28(37)38)34-27(36)20-19-23(32)31(41)42/h7-8,10-14,17,23-26,35H,3-6,9,15-16,18-22,32H2,1-2H3,(H,33,40)(H,34,36)(H,37,38)(H,41,42)/b8-7-,11-10-,13. InChi Key: NEICPYXCIYSWOH-LZHUJPGBSA-N.
Keywords: LTC4 methyl ester, 5S-hydroxy-6R-(S-glutathionyl)-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 10007164


Application: Bioactive lipid assays
MW: 639.8 D
Formula: C31H49N3O9S
Purity: >97%
Format: Solution

Database Information

CAS : 73958-10-8| Find alternatives
KEGG ID : K00807 | Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225
P Phrases: P210, P233, P240, P241, P242, P243, P280, P303+361+353, P370+378, P403+235, P501
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