Leukotriene A4 methyl ester

Leukotriene A4 methyl ester
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay20010-25 25 µg -

6 - 10 business days*

104.00€
Cay20010-50 50 µg -

6 - 10 business days*

198.00€
Cay20010-100 100 µg -

6 - 10 business days*

374.00€
Cay20010-500 500 µg -

6 - 10 business days*

1,660.00€
 
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic... more
Product information "Leukotriene A4 methyl ester"
Leukotriene A4 (LTA4) is synthesized in mast cells, eosinophils, and neutrophils from arachidonic acid by 5-lipoxygenase (5-LO), which exhibits both lipoxygenase and LTA4 synthase activities. LTA4 is rapidly metabolized by LTA4 hydrolase or LTC4 synthase to LTB4 or LTC4, respectively. LTA4, from leukocytes, is known to undergo transcellular metabolism in platelets, erythrocytes, and endothelial cells. Further metabolism of LTA4 by 15-LO leads to lipoxin biosynthesis. LTA4 as a free acid is highly unstable. The methyl ester is stable and can be readily hydrolyzed to the free acid as needed. Formal Name: 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester. CAS Number: 73466-12-3. Synonyms: LTA4 methyl ester. Molecular Formula: C21H32O3. Formula Weight: 332.5. Purity: >97%. Formulation: A solution in hexane containing 1% triethylamine. Solubility: Acetone: >50 mg/ml, DMF: >50 mg/ml, DMSO: >50 mg/ml, Ethanol: >50 mg/ml, PBS pH 7.2: insoluble and unstable.. lambdamax: 279 nm. SMILES: CCCCC/C=C\C/C=C\C=C\C=C\[C@H](O1)[C@@H]1CCCC(OC)=O. InChi Code: InChI=1S/C21H32O3/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-19-20(24-19)17-15-18-21(22)23-2/h7-8,10-14,16,19-20H,3-6,9,15,17-18H2,1-2H3/b8-7-,11-10-,13-12+,16-14+/t19-,20-/m0/s1. InChi Key: WTKAVFHPLJFCMZ-NIBLXIPLSA-N.
Keywords: LTA4 methyl ester, 5S-trans-5,6-oxido-7E,9E,11Z,14Z-eicosatetraenoic acid, methyl ester
Supplier: Cayman Chemical
Supplier-Nr: 20010

Properties

Application: Bioactive lipid assays
MW: 332.5 D
Formula: C21H32O3
Purity: >97%
Format: Solution

Database Information

CAS : 73466-12-3| Find alternatives

Handling & Safety

Storage: -80°C
Shipping: -20°C (International: -80°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H225, H304, H315, H336, H361, H373, H411
P Phrases: P201, P202, P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P273, P280, P301+310, P302+352, P303+361+353, P304+340, P308+313, P312, P314, P321, P331, P332+313, P362+364, P370+378, P391, P403+233, P403+235, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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