IZ-Chol

IZ-Chol is an ionizable cationic lipid (pKas = 7.29 and 3.96) containing cholesterol (Cay-9003100, Cay-39088). LNPs containing IZ-chol can be complexed with DNA, with the plasmid-binding efficacy dependent, in part, on the type of helper lipids in the LNP formulation.Formal Name: [3-(1H-imidazol-1-yl)propyl]carbamate, cholest-5-en-3beta-ol. CAS Number: 191990-35-9. Synonyms: IZ-Cholesterol. Molecular Formula: C34H55N3O2. Formula Weight: 537.8. Purity: >98%. Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: Soluble: >10 mg/ml. SMILES: C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(NCCCN5C=NC=C5)=O)CC[C@]4(C)[C@@]3([H])CC[C@]12C. InChi Code: InChI=1S/C34H55N3O2/c1-24(2)8-6-9-25(3)29-12-13-30-28-11-10-26-22-27(14-16-33(26,4)31(28)15-17-34(29,30)5)39-32(38)36-18-7-20-37-21-19-35-23-37/h10,19,21,23-25,27-31H,6-9,11-18,20,22H2,1-5H3,(H,36,38)/t25-,27+,28+,29-,30+,31+,33+,34-/m1/s1. InChi Key: HWACRISJBCSLAW-DYQRUOQXSA-N.