Isoliquiritin

Isoliquiritin is a flavonoid that has been found in G. uralensis roots and has diverse biological activities. It inhibits LPS-induced nitrite and prostaglandin E2 (PGE2, Cay-14010) production in RAW 264.7 cells when used at a concentration of 1.6 µM. Isoliquiritin (5-500 µg/ml) inhibits tube formation by isolated rat aortic endothelial cells. In vivo, isoliquiritin reduces carmine content, a marker of blood vessel formation, and pouch fluid weight in a mouse model of adjuvant-induced pouch granuloma formation (ED50s = 1.46 and 0.771 mg/kg, respectively). It increases cortical, hippocampal, and hypothalamic serotonin (5-HT) and norepinephrine levels and decreases immobility time in the forced swim and tail suspension tests in mice when administered at doses ranging from 10 to 40 mg/kg.Formal Name: (2E)-1-(2,4-dihydroxyphenyl)-3-[4-(beta-D-glucopyranosyloxy)phenyl]-2-propen-1-one. CAS Number: 5041-81-6. Synonyms: Isoliquiritoside. Molecular Formula: C21H22O9. Formula Weight: 418.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.50 mg/ml. lambdamax: 229, 362 nm. SMILES: OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC2=CC=C(/C=C/C(C3=C(O)C=C(O)C=C3)=O)C=C2)O1. InChi Code: InChI=1S/C21H22O9/c22-10-17-18(26)19(27)20(28)21(30-17)29-13-5-1-11(2-6-13)3-8-15(24)14-7-4-12(23)9-16(14)25/h1-9,17-23,25-28H,10H2/b8-3+/t17-,18-,19+,20-,21-/m1/s1. InChi Key: YNWXJFQOCHMPCK-LXGDFETPSA-N. Origin: Plant/Glycyrrhiza glabra.