Hydrocortisone 21-hemisuccinate (sodium salt)

Hydrocortisone 21-hemisuccinate is a water-soluble form of the endogenous hormone cortisol. It can bind to glucocorticoid receptors, initiating the transcription of anti-inflammatory and immunosuppressive mediators and inhibiting proinflammatory cytokine activity (IC50 = 6.7 µM for IL-6). It is commonly used to supplement media for long-term epithelial or endothelial cell cultures and to differentiate pluripotent stem cells.Formal Name: 21-(3-carboxy-1-oxopropoxy)-11beta,17-dihydroxy-pregn-4-ene-3,20-dione, monosodium salt. CAS Number: 125-04-2. Synonyms: Cortisol 21-hemisuccinate, Hydrocortisone sodium succinate, ST51037292, U-4905. Molecular Formula: C25H33O8 . Na. Formula Weight: 484.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 242 nm. SMILES: [H][C@]12[C@@]([C@@](CC[C@]3(O)C(COC(CCC([O-])=O)=O)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O.[Na+]. InChi Code: InChI=1S/C25H34O8.Na/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30,/h11,16-18,22,27,32H,3-10,12-13H2,1-2H3,(H,29,30),/q,+1/p-1/t16-,17-,18-,22+,23-,24-,25-,/m0./s1. InChi Key: HHZQLQREDATOBM-CODXZCKSSA-M.