Hexafluoropropylene Oxide Dimer Acid

Hexafluoropropylene oxide dimer acid (HFPO-DA) is a perfluoroalkyl ether carboxylic acid (PFECA). It induces apoptosis and increases the levels of reactive oxygen species (ROS) in HepG2 cells when used at a concentration of 250 µM. HFPO-DA (4 mg/kg per egg) decreases right ventricular wall thickness, increases heart rate, and induces hepatic lipid accumulation in hatchling chickens, effects that can be prevented by knockdown of the gene encoding peroxisome proliferator-activated receptor alpha (Ppara). It decreases the percent survival of zebrafish embryos (LC50 = 7,651 mg/L). HFPO-DA (250 mg/kg) decreases average birthweight, survival time, and serum glucose levels, as well as increases serum cholesterol and triglyceride levels, in neonatal rats when administered to pregnant dams. It has been found as a contaminant in sea and river water.Formal Name: 2,3,3,3-tetrafluoro-2-(1,1,2,2,3,3,3-heptafluoropropoxy)-propanoic acid. CAS Number: 13252-13-6. Synonyms: FRD-903, HFPO-DA, Perfluoro-2-propoxypropanoic Acid, PFPrOPrA. Molecular Formula: C6HF11O3. Formula Weight: 330.1. Formulation: (Request formulation change), A liquid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. SMILES: O=C(C(OC(F)(C(F)(C(F)(F)F)F)F)(C(F)(F)F)F)O. InChi Code: InChI=1S/C6HF11O3/c7-2(1(18)19,4(10,11)12)20-6(16,17)3(8,9)5(13,14)15/h(H,18,19). InChi Key: CSEBNABAWMZWIF-UHFFFAOYSA-N.