Glucosamine Cholesterol

Glucosamine cholesterol is a glucosamine-based lipid conjugate that has been used in the formation of lipid nanoparticles (LNPs). It forms a stable, ordered bilayer with the glucosamine moiety facing outward to facilitate recognition by glucose transporter 1 (GLUT1) on cells. LNPs containing glucosamine cholesterol and encapsulating ceramide induce apoptosis in hypoxic human A549 lung carcinoma cells and A549-derived side population cells, also known as cancer stem cells (CSCs), but not hypoxic mouse L-929 fibroblasts. LNPs containing glucosamine cholesterol and encapsulating paclitaxel (Cay-10461) and carboplatin (Cay-13112) reduce tumor volume and increase the number of tumor-associated cytotoxic T cells in an LL/2 murine lung carcinoma model.Formal Name: 2-[[4-[(3beta)-cholest-5-en-3-yloxy]-1,4-dioxobutyl]amino]-2-deoxy-D-glucopyranose. CAS Number: 1257309-90-2. Molecular Formula: C37H61NO8. Formula Weight: 647.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble (sonicate). SMILES: C[C@]12CC[C@H](OC(CCC(N[C@H]3C(O)O[C@H](CO)[C@@H](O)[C@@H]3O)=O)=O)CC1=CC[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@@H](CCCC(C)C)C. InChi Code: InChI=1S/C37H61NO8/c1-21(2)7-6-8-22(3)26-11-12-27-25-10-9-23-19-24(15-17-36(23,4)28(25)16-18-37(26,27)5)45-31(41)14-13-30(40)38-32-34(43)33(42)29(20-39)46-35(32)44/h9,21-22,24-29,32-35,39,42-44H,6-8,10-20H2,1-5H3,(H,38,40)/t22-,24+,25+,26-,27+,28+,29-,32-,33-,34-,35?,36+,37-/m1/s1. InChi Key: CEZJGMHPGUGAEW-ACSCFQKYSA-N.