GL67

GL67 is a multivalent ionizable cationic lipid composed of spermine (Cay-18041) conjugated to cholesterol (Cay-9003100). It has been used in the generation of liposomes complexed with plasmid DNA for use in vitro and in vivo. GL67 has also been used in combination with DC-Chol (Cay-16943) and 1,2-dioloeyl-sn-glycero-3-PE (1,2-DOPE, Cay-15091) in the generation of lipid nanocarriers for the delivery of siRNA to A549 lung cancer cells. GL67-containing liposomes, in complex with plasmid DNA for the gene encoding cystic fibrosis transmembrane conductance regulator (CFTR), leads to the expression of functional wild-type CFTR in HEK293 cells. Aerosol administration of GL67-containing liposomes, in complex with plasmid DNA for the gene encoding CFTR, increases trachea and whole lung mRNA levels of CFTR.Formal Name: 3beta-[(3-aminopropyl)[4-[(3-aminopropyl)amino]butyl]carbamate] cholest-5-en-3-ol. CAS Number: 179075-30-0. Synonyms: N4-Spermine Cholesteryl Carbamate. Molecular Formula: C38H70N4O2. Formula Weight: 615.0. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: 10 mg/ml. SMILES: C[C@H](CCCC(C)C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](OC(N(CCCN)CCCCNCCCN)=O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C38H70N4O2/c1-28(2)11-8-12-29(3)33-15-16-34-32-14-13-30-27-31(17-19-37(30,4)35(32)18-20-38(33,34)5)44-36(43)42(26-10-22-40)25-7-6-23-41-24-9-21-39/h13,28-29,31-35,41H,6-12,14-27,39-40H2,1-5H3/t29-,31+,32+,33-,34+,35+,37+,38-/m1/s1. InChi Key: KBBLYWGVXTZWCU-HMVYLTCSSA-N.