Ganoderic Acid DM

Ganoderic acid DM is a triterpenoid that has been found in G. lucidum and has diverse biological activities. It inhibits 5alpha-reductase and HMG-CoA reductase (IC50s = 10.6 and 9.5 µM, respectively) and binds to the ligand-binding domain of the androgen receptor in a fluorescence polarization assay. Ganoderic acid suppresses osteoclastogenesis of RAW 264.7 cells when used at a concentration of 12.5 µM and is cytotoxic to K562 leukemia and PC3 prostate cancer cells (IC50s = 18.8 and 81.6 µM, respectively). It reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA, Cay-10008014) in mice (ID50 = 0.08 mg/ear).Formal Name: 3,7-dioxo-lanosta-8,24E-dien-26-oic acid. CAS Number: 173075-45-1. Molecular Formula: C30H44O4. Formula Weight: 468.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. lambdamax: 217, 251 nm. SMILES: C[C@]12C3=C(CC[C@@]1([C@]([C@@H](CC/C=C(C)/C(O)=O)C)([H])CC2)C)[C@@]4([C@@](C(C)(C(CC4)=O)C)([H])CC3=O)C. InChi Code: InChI=1S/C30H44O4/c1-18(9-8-10-19(2)26(33)34)20-11-16-30(7)25-21(12-15-29(20,30)6)28(5)14-13-24(32)27(3,4)23(28)17-22(25)31/h10,18,20,23H,8-9,11-17H2,1-7H3,(H,33,34)/b19-10+/t18-,20-,23+,28-,29-,30+/m1/s1. InChi Key: ZTKZZRIVAYGFSF-PIPDTRPPSA-N. Origin: Plant/Unspecified sp..