Ganoderenic Acid A

Ganoderenic acid A is a triterpenoid originally isolated from G. lucidum that has enzyme inhibitory activities. It is an inhibitor of beta-glucuronidase (IC50 = 0.12 mg/ml in rat liver microsomes). Ganoderenic acid A (100 mg/kg) reduces increases in serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) in a rat model of liver injury induced by carbon tetrachloride (CCl4). It also inhibits aldose reductase by 54.2% when used at a concentration of 100 µg/ml.Formal Name: (7beta,15alpha,20E)-7,15-dihydroxy-3,11,23-trioxo-lanosta-8,20(22)-dien-26-oic acid. CAS Number: 100665-40-5. Molecular Formula: C30H42O7. Formula Weight: 514.7. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: soluble. lambdamax: 247 nm. SMILES: CC12C(C[C@H](O)C(C([C@@H](O)CC3/C(C)=C\C(CC(C)C(O)=O)=O)(C)C3(C)C4)=C2C4=O)C(C)(C)C(CC1)=O. InChi Code: InChI=1S/C30H42O7/c1-15(10-17(31)11-16(2)26(36)37)18-12-23(35)30(7)25-19(32)13-21-27(3,4)22(34)8-9-28(21,5)24(25)20(33)14-29(18,30)6/h10,16,18-19,21,23,32,35H,8-9,11-14H2,1-7H3,(H,36,37)/b15-10-/t16?,18?,19-,21?,23-,28?,29?,30?/m0/s1. InChi Key: OVUOUFPIPZJGME-WHWWCJHXSA-N. Origin: Fungus/Ganoderma lucidum.