gamma-Linolenic Acid

gamma-Linolenic acid (GLA) is an omega-6 fatty acid which can be elongated to arachidonic acid for endogenous eicosanoid synthesis. It is a weak LTB4 receptor antagonist, inhibiting [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 µM. GLA produces 53% inhibition at a 1 mg/kg dose in an in vivo model of LTB4-induced bronchoconstriction. Formal Name: 6Z,9Z,12Z-octadecatrienoic acid. CAS Number: 506-26-3. Synonyms: GLA. Molecular Formula: C18H30O2. Formula Weight: 278.4. Purity: >98%. Formulation: A solution in ethanol. Solubility: 0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid), DMF: >100 mg/ml (from Oleic Acid), DMSO: >100 mg/ml (from Oleic Acid), Ethanol: >100 mg/ml (from Oleic Acid), PBS pH 7.2: <100 µg/ml (from Oleic Acid). SMILES: CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O. InChi Code: InChI=1S/C18H30O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10,12-13H,2-5,8,11,14-17H2,1H3,(H,19,20)/b7-6-,10-9-,13-12-. InChi Key: VZCCETWTMQHEPK-QNEBEIHSSA-N. Side Chain Carbon Sum: 18:3.