Fz25

Fz25 is a triazole-modified sterol and an anticancer agent. It inhibits the proliferation of A2780 ovarian and HT-29 colorectal cancer cells (IC50s = 15.29 and 15.98 µM, respectively). Fz25 decreases the phosphorylation of EGFR and STAT3 in A2780 cells when used at a concentration of 30.58 µM and phosphorylation of ERK, STAT3, and mammalian target of rapamycin (mTOR) in HT-29 cells at 31.96 µM. It reduces the efflux activity of P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), in a reporter assay using HEK293 cells when used at a concentration of 10 µM.Formal Name: (17beta)-3-(phenylmethoxy)-17-(1H-1,2,3-triazol-5-yl)-estra-1,3,5(10)-trien-17-ol. CAS Number: 2762498-70-2. Molecular Formula: C27H31N3O2. Formula Weight: 429.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 25 mg/ml, Ethanol: 5 mg/ml. lambdamax: 280 nm. SMILES: C[C@@]12[C@](CC[C@@]2(O)C3=CN=NN3)([H])[C@@]4([H])[C@](C5=CC=C(OCC6=CC=CC=C6)C=C5CC4)([H])CC1. InChi Code: InChI=1S/C27H31N3O2/c1-26-13-11-22-21-10-8-20(32-17-18-5-3-2-4-6-18)15-19(21)7-9-23(22)24(26)12-14-27(26,31)25-16-28-30-29-25/h2-6,8,10,15-16,22-24,31H,7,9,11-14,17H2,1H3,(H,28,29,30)/t22-,23-,24+,26+,27-/m1/s1. InChi Key: WILNBQOUIDDELX-OBOOOKMBSA-N.