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FO-32 is an ionizable cationic lipid (pKa = 6.36) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. Intranasal administration of LNPs containing FO-32 and encapsulating reporter mRNA accumulate in nasal epithelial tissue and lungs in mice. Nebulized administration of FO-32-containing LNPs encapsulating Cre mRNA induce the expression of tdTomato in the lungs of ferrets engineered to express tdTomato upon Cre-mediated recombination.. Solulibility: Methyl Acetate: Soluble: =10 mg/ml: .
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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