Fludrocortisone

Fludrocortisone is a synthetic mineralocorticoid. Dietary administration of fludrocortisone (10 µg/kg per day) reduces tympanic membrane thickness and fluid area in a mouse model of S. pneumoniae-induced middle ear inflammation. Formulations containing fludrocortisone have been used in the treatment of Addison's disease.Formal Name: (11beta)-9-fluoro-11,17,21-trihydroxy-pregn-4-ene-3,20-dione. CAS Number: 127-31-1. Synonyms: Astonin-H, 9alpha-Fludrocortisone, Fluohydrocortisone, Fluorohydrocortisone, NSC 11318. Molecular Formula: C21H29FO5. Formula Weight: 380.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: slightly soluble, Ethanol: slightly, sonicated, Methanol: slightly, sonicated. SMILES: F[C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)C[C@@H]2O)([H])CCC4=CC(CC[C@@]41C)=O. InChi Code: InChI=1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1. InChi Key: AAXVEMMRQDVLJB-BULBTXNYSA-N.