Filipin III

Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay70440-500 500 µg -

6 - 10 business days*

Cay70440-1 1 mg -

6 - 10 business days*

Cay70440-5 5 mg -

6 - 10 business days*

Cholesterol is both an important structural component of cell membranes and an early intermediate... more
Product information "Filipin III"
Cholesterol is both an important structural component of cell membranes and an early intermediate in hormone and bile acid biosynthesis. The localization and measurement of cholesterol in cells is therefore of great interest. Filipin is the collective name given to four isomeric polyene macrolides isolated from cultures of S. filipinensis, Filipin III is the predominant isomer and the one used in most studies. Filipin binds to cholesterol in membranes, forming ultrastructural aggregates and complexes which can be visualized by freeze-fracture electron microscopy. The binding of cholesterol also decreases the intrinsic fluorescence of Filipin, and this property has also been used to detect cholesterol in membrane fractions. Formal Name: 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,21E,23E,25E-pentaen-2-one. CAS Number: 480-49-9. Molecular Formula: C35H58O11. Formula Weight: 654.8. Purity: >90%. Formulation: A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 72) (1:4): 0.4 mg/ml, Ethanol: 2 mg/ml. lambdamax: 323, 339, 357 nm. SMILES: O[C@@H]1/C(C)=C/C=C/C=C/C=C/C=C/[C@H](O)[C@@H](C)OC([C@@]([C@H](O)CCCCC)([H])[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C[C@@H](O)C1)=O. InChi Code: InChI=1S/C35H58O11/c1-4-5-11-16-31(42)34-33(44)22-29(40)20-27(38)18-25(36)17-26(37)19-28(39)21-32(43)23(2)14-12-9-7-6-8-10-13-15-30(41)24(3)46-35(34)45/h6-10,12-15,24-34,36-44H,4-5,11,16-22H2,1-3H3/b7-6+,10-8+,12-9+,15-13+,23-14+/t24-,25+,26-,27+,28-. InChi Key: IMQSIXYSKPIGPD-YQRUMEKGSA-N.
Keywords: 4S,6S,8S,10R,12R,14R,16S,27S-octahydroxy-3R-(1R-hydroxy-hexyl)17,28R-dimethyl-oxacyclooctacosa-17E,19E,21E,21E,23E,25E-pentaen-2-one
Supplier: Cayman Chemical
Supplier-Nr: 70440


Application: Bioactive lipid assays
MW: 654.8 D
Formula: C35H58O11
Purity: >90%
Format: Crystalline Solid

Database Information

CAS : 480-49-9| Find alternatives

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Warning
GHS Hazard Pictograms:
H Phrases: H315, H319, H335
P Phrases: P261, P264, P271, P280, P302+352, P304+340, P305+351+338, P312, P321, P332+313, P337+313, P362+364, P403+233, P405, P501
Our products are for laboratory research use only: Not for administration to humans!
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