Etiocholanolone

Etiocholanolone is an androgenically inactive metabolite of testosterone and androstenedione and the 5beta epimer of androsterone (Cay-15872). It increases the frequency of long channel openings and potentiates GABA-induced chloride currents in HEK293 cells expressing rat alpha1beta2gamma2L subunit-containing GABAA receptors when used at a concentration of 10 µM. Etiocholanolone is protective against seizures induced by 6 Hz electroshock or pentylenetetrazol (PTZ, ED50s = 76.9 and 139 mg/kg, respectively). It is also pyretic in an IL-1-dependent manner, inducing increases in body temperature in rhesus macaques but not squirrel monkeys that lack testosterone and androstenedione metabolizing enzymes.Formal Name: (5beta)-3alpha-hydroxy-androstan-17-one. CAS Number: 53-42-9. Synonyms: 5beta-Androsterone, 3alpha-Etiocholanolone, NSC 50908. Molecular Formula: C19H30O2. Formula Weight: 290.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: 10 mg/ml. SMILES: C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@](CC3)(C(CC4)=O)C. InChi Code: InChI=1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12-16,20H,3-11H2,1-2H3/t12-,13-,14+,15+,16+,18+,19+/m1/s1. InChi Key: QGXBDMJGAMFCBF-BNSUEQOYSA-N.