Eriodictyol 7-O-glucoside

Eriodictyol 7-O-glucoside is a flavanone glucoside that has been found in V. coloratum and has diverse biological activities. It scavenges hydroxyl and superoxide anion radicals in cell-free assays (IC50s = 0.28 and 0.3 mM, respectively). Eriodictyol 7-O-glucoside activates nuclear factor E2-related factor 2 (Nrf2) in a reporter assay. It protects against cytotoxicity induced by cisplatin (Cay-13119) in human renal mesangial cells (HRMCs), but not A549 lung or MDA-MB-231 breast cancer cells, when used at a concentration of 80 µM. Eriodictyol 7-O-glucoside (30 mg/kg) attenuates neurological deficits and reduces infarct volume in a rat model of cerebral ischemia induced by middle cerebral artery occlusion (MCAO).Formal Name: (2S)-2-(3,4-dihydroxyphenyl)-7-(beta-D-glucopyranosyloxy)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one. CAS Number: 38965-51-4. Synonyms: 7-O-beta-D-Glucopyranosyl-eriodictyol, (2S)-Eriodictyol 7-O-beta-D-glucopyranoside. Molecular Formula: C21H22O11. Formula Weight: 450.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10mM. lambdamax: 283 nm. SMILES: OC1=C2C(O[C@@H](CC2=O)C3=CC(O)=C(O)C=C3)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1. InChi Code: InChI=1S/C21H22O11/c22-7-16-18(27)19(28)20(29)21(32-16)30-9-4-12(25)17-13(26)6-14(31-15(17)5-9)8-1-2-10(23)11(24)3-8/h1-5,14,16,18-25,27-29H,6-7H2/t14-,16+,18+,19-,20+,21+/m0/s1. InChi Key: RAFHNDRXYHOLSH-SFTVRKLSSA-N. Origin: Plant/Viscµm articulatum.