Epigoitrin

Epigoitrin is an alkaloid that has been found in Crambe abyssinica and has diverse biological activities. It decreases norepinephrine formation by bovine dopamine-beta-hydroxylase in a cell-free assay when used at a concentration of 0.1 mM. Epigoitrin inhibits the proliferation of RAW 264.7 macrophages (IC50 = ~1 mM). It increases serum cholesterol levels and liver and thyroid weight, as well as decreases serum thyroxine levels, in rats. Epigoitrin (176 mg/kg) improves survival in mice made susceptible to influenza A H1N1 infection by restraint stress. It also prolongs pentobarbital-induced sleeping time in male, but not female, rats.Formal Name: (5R)-5-ethenyl-2-oxazolidinethione. CAS Number: 1072-93-1. Synonyms: Ba 51-090278, (R)-Goitrin. Molecular Formula: C5H7NOS. Formula Weight: 129.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 2 mg/ml, DMSO: 5 mg/ml, Ethanol: 3 mg/ml, PBS (pH 7.2): insol. lambdamax: 245 nm. SMILES: C=C[C@H]1OC(NC1)=S. InChi Code: InChI=1S/C5H7NOS/c1-2-4-3-6-5(8)7-4/h2,4H,1,3H2,(H,6,8)/t4-/m1/s1. InChi Key: UZQVYLOFLQICCT-SCSAIBSYSA-N. Origin: Plant/Strobilanthes cusia.