DSPE-PEG(2000)-Mannose

DSPE-PEG(2000)-mannose is a PEGylated and mannosylated form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE. Cay-15095) that has been used in the generation of liposomes and lipid nanoparticles (LNPs) for the delivery of peptides, oligodeoxynucleotides, and siRNA in vitro and in vivo. Fluorescently labeled LNPs containing DSPE-PEG(2000)-mannose selectively accumulate in the liver and spleen over the brain, lungs, heart, kidney, and pancreas in mice. Immunization with liposomes containing DSPE-PEG(2000)-mannose and encapsulating human papilloma virus type 16 (HPV16) E7 peptide and CpG oligodeoxynucleotide as an adjuvant decrease tumor size, intratumoral CD4+ or CD8+ T cells, and intratumoral angiogenesis in a murine lung cancer model using TC-1 cells, which express HPV16 E6 and E7 peptides. Formal Name: alpha-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-omega-[2-[[[[4-(alpha-D-mannopyranosyloxy)phenyl]amino]thioxomethyl]amino]ethoxy]-poly(oxy-1,2-ethanediyl). CAS Number: 1829524-73-3. Synonyms: 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-Mannose 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-Polyethylene Glycol-2000-Mannose DSPE-PEG2000-Mannose 1,2-DSPE-PEG(2000)-Mannose. Molecular Formula: (C2H4O)nC57H102N3O16PS. Purity: >95%. Formulation (Request formulation change): A solid. Solubility: DMSO: Slightly soluble: 0.1-1 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml. SMILES: O=C(NCCOP(O)(OC[C@@H](COC(CCCCCCCCCCCCCCCCC)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O)OCCOCCNC(NC1=CC=C(O[C@@H]2[C@@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C=C1)=S. Storage: -20°C. Stability: > 4 years.