DMT7

An ionizable cationic lipid (pKa = 6.5), has been used in the generation of LNPs for the delivery of mRNA and anticancer agents in vivo, LNPs containing DMT7 and encapsulating mRNA encoding Il-12 and MSA-2 decrease tumor volume, lung metastatic nodule numbers, and lung levels of CD4+ and CD8+ T cells in a 4T1 breast cancer mouse xenograft model of lung metastasis, the same LNPs decrease the number of Tregs, increase the number of tumor-associated M1 macrophages, and increase intratumoral levels of Il-12, Il-2, Tnf-a, and Ifn-? in a B16/F10 murine melanoma model. Formulation: A solution in ethanol. InChI: InChI=1S/C42H79N3S/c1-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-35-37-41(44-42(46)43-39-40-45(3)4)38-36-34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-2/h13-16,19-22,41H,5-12,17-18,23-40H2,1-4H3,(H2,43,44,46)/b15-13-,16-14-,21-19-,22-20. InChIKey: KEVKDMPMVGLRPK-KWXKLSQISA-N. SMILES: CCCCC/C=C\C/C=C\CCCCCCCCC(CCCCCCCC/C=C\C/C=C\CCCCC)NC(NCCN(C)C)=S