Diflucortolone 21-valerate

Diflucortolone 21-valerate is a glucocorticoid. It has anti-inflammatory effects in a rat model of croton oil-induced ear edema when applied topically (ED50 = 9.7 µg/ml). Diflucortolone 21-valerate (0.1%) also induces skin inflammation and thins the epidermis in hairless dogs following chronic topical administration and increases allergic- and non-allergic-mediated skin inflammation in mouse models of atopic dermatitis when applied topically prior to and following sensitization. Formulations containing diflucortolone 21-valerate have been used in the treatment of inflammatory or allergic skin conditions.Formal Name: 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21-[(1-oxopentyl)oxy]-pregna-1,4-diene-3,20-dione. CAS Number: 59198-70-8. Molecular Formula: C27H36F2O5. Formula Weight: 478.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMF:PBS (pH 7.2) (1:3): 0.25 mg/ml, DMSO: 10 mg/ml. lambdamax: 237 nm. SMILES: F[C@@]12[C@](C[C@@H](C([C@@]2(C=C3)C)=CC3=O)F)([H])[C@@]4([H])[C@](C[C@@H]1O)([C@H]([C@@H](C4)C)C(COC(CCCC)=O)=O)C. InChi Code: InChI=1S/C27H36F2O5/c1-5-6-7-23(33)34-14-21(31)24-15(2)10-17-18-12-20(28)19-11-16(30)8-9-26(19,4)27(18,29)22(32)13-25(17,24)3/h8-9,11,15,17-18,20,22,24,32H,5-7,10,12-14H2,1-4H3/t15-,17+,18+,20+,22+,24-,25+,26+,27+/m1/s1. InChi Key: HHJIUUAMYGBVSD-YTFFSALGSA-N.