Dexamethasone-d4

Dexamethasone-d4 is intended for use as an internal standard for the quantification of dexamethasone (Cay-11015) by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (Kd = 5 nM versus 17 nM, respectively). Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.Formal Name: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-pregna-1,4-diene-3,20-dione-4,6,21,21-d4. CAS Number: 2483831-63-4. Molecular Formula: C22H25D4FO5. Formula Weight: 396.5. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMF: 25 mg/ml, DMSO: 30 mg/ml, Ethanol: 3 mg/ml. SMILES: O=C1C=C[C@@]2(C)C(C([2H])C[C@]3([H])[C@]2(F)[C@@H](O)C[C@@]4(C)[C@@]3([H])C[C@@H](C)[C@]4(O)C(C([2H])([2H])O)=O)=C1[2H]. InChi Code: InChI=1S/C22H29FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h6-7,9,12,15-17,24,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1/i4D,9D,11D2/t4?,12-,15+,16+,17+,19+,20+,21+,22+. InChi Key: UREBDLICKHMUKA-SOEBWSEYSA-N.