DCP-LA

DCP-LA is a derivative of linoleic acid (Cay-90150) and a potent activator of PKCepsilon. It activates PKCepsilon with a greater than 7-fold stronger potency over PKCalpha, betaI, betaII, gamma, delta, µ, eta, and zeta in a cell-free assay. DCP-LA activates PKC in PC12 cells in a concentration-dependent manner, an effect that is blocked by the PCK inhibitor bisindolylmaleimide I (Cay-13298, Cay-21180) and a PCKepsilon-selective peptide inhibitor. It decreases intracellular levels of amyloid-beta (Abeta) in Neuro2 neuroblastoma cells transfected with human APPSwe/PS1Delta9. DCP-LA also stimulates hippocampal glutamate release, striatal dopamine release, and hypothalamic serotonin release in rat brain slices in a PKC- and alpha7-containing nicotinic acetylcholine receptor-dependent manner. In vivo, DCP-LA (3 mg/kg, i.p.) prevents synaptic loss and amyloid plaque formation and decreases escape latency in the Morris water maze in the 5XFAD transgenic mouse model of Alzheimer's disease.Formal Name: 2-[(2-pentylcyclopropyl)methyl]-cyclopropaneoctanoic acid. CAS Number: 28399-31-7. Synonyms: FA 20:2, FR 236924. Molecular Formula: C20H36O2. Formula Weight: 308.5. Purity: >95%. Formulation: (Request formulation change), A solution in ethanol. Solubility: DMF: 50 mg/ml, DMSO: 25 mg/ml, Ethanol: 10 mg/ml. SMILES: CCCCCC(C1)C1CC(C2)C2CCCCCCCC(O)=O. InChi Code: InChI=1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22). InChi Key: CONYTTFKIUJZOF-UHFFFAOYSA-N.