Cortisone

Cortisone is a glucocorticoid receptor-inert precursor and metabolite of the glucocorticoid cortisol (hydrocortisone, Cay-20739). Cortisone is converted to glucocorticoid receptor-active cortisol by 11beta-hydroxysteroid dehydrogenase (11beta-HSD1) and is regenerated by metabolism of cortisol by 11beta-HSD2 in vivo.Formal Name: 17,21-dihydroxy-pregn-4-ene-3,11,20-trione. CAS Number: 53-06-5. Synonyms: 17alpha-hydroxy-11-Dehydrocorticosterone, Kendall's Compound E, 4-Pregnene-17alpha,21-diol-3,11,20-trione, Reichstein's Substance Fa. Molecular Formula: C21H28O5. Formula Weight: 360.4. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml. lambdamax: 238 nm. SMILES: [H][C@]12[C@@]([C@@](CC[C@]3(O)C(CO)=O)([H])[C@]3(C)CC2=O)([H])CCC4=CC(CC[C@@]41C)=O. InChi Code: InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1. InChi Key: MFYSYFVPBJMHGN-ZPOLXVRWSA-N.