Cerevisterol

Cerevisterol is an ergosterol fungal metabolite originally isolated from S. cerevisiae that has diverse biological activities, including antimicrobial, anti-inflammatory, and anticancer properties. It is active against the bacteria S. typhi, S. aureus, and E. faecalis (MICs = 25, 25, and 50 µg/ml, respectively) and the fungus A. niger (MIC = 25 µg/ml), but has no effect on the bacteria E. coli, P. aeruginosa, S. pyogenes, K. pneumoniae, and B. subtilis, or the fungi C. albicans, A. flavus, and A. tamarii when used at concentrations up to 400 µg/ml. Cerevisterol (2-20 µM) inhibits LPS-induced increases in the levels of nitric oxide (NO), TNF-alpha, IL-6, IL-10, and prostaglandin E2 (PGE2, Cay-14010) in RAW 264.7 cells. It inhibits proliferation of MCF-7, MDA-MB-231, and Caco-2 cancer cells (EC50s = 64.5, 52.4, and 37.6 µM, respectively), but not PC3, PANC-1, or A549 cells (IC50 = >100 µM for all).,Formal Name: (3beta,5alpha,6beta,22E)-ergosta-7,22-diene-3,5,6-triol. CAS Number: 516-37-0. Molecular Formula: C28H46O3. Formula Weight: 430.7. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: C[C@H](/C=C/[C@H](C)C(C)C)[C@@]1([H])CC[C@@]2([H])C3=C[C@@H](O)[C@@]4(O)C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C. InChi Code: InChI=1S/C28H46O3/c1-17(2)18(3)7-8-19(4)22-9-10-23-21-15-25(30)28(31)16-20(29)11-14-27(28,6)24(21)12-13-26(22,23)5/h7-8,15,17-20,22-25,29-31H,9-14,16H2,1-6H3/b8-7+/t18-,19+,20-,22+,23-,24-,25+,26+,27+,28-/m0/s1. InChi Key: ARXHRTZAVQOQEU-BRVLHLJYSA-N. Origin: Fungus/Trichoderma sp..