Capsaicin-d3

Capsaicin-d3 is intended for use as an internal standard for the quantification of capsaicin (Cay-92350, Cay-10010743) by GC- or LC-MS. Capsaicin is a terpene alkaloid that has been found in Capsicum and has diverse biological activities. It induces inward currents in HEK293 cells expressing rat transient receptor potential vanilloid 1 (TRPV1, EC50 = 0.64 µM at neutral pH), an effect that can be blocked by the TRPV1 inhibitor A-425619. Capsaicin (10 and 50 µM) decreases LPS-induced prostaglandin E2 (PGE2, Cay-14010) production, as well as reduces LPS- and IFN-induced nitric oxide (NO) release in isolated mouse peritoneal macrophages. Capsaicin induces substance P (Cay-24035) release in rat spinal cord slices with an EC50 value of 2.3 µM. It reduces acetylcholine- or phenylquinone-induced writhing (ED50s = 1.33 and 1.38 mg/kg, respectively, s.c.) but has no effect on the latency to paw withdrawal in the hot plate test in mice (ED50 = >20 mg/kg, s.c.). Formulations containing capsaicin have been used in the treatment of nerve pain associated with shingles.Formal Name: N-[[4-hydroxy-3-(methoxy-d3)phenyl]methyl]-8-methyl-6-nonenamide. CAS Number: 1217899-52-9. Molecular Formula: C18H24D3NO3. Formula Weight: 308.4. Purity: >99% deuterated forms (d1-d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, DMF: soluble, DMSO: soluble, Ethyl Acetate: soluble, Methanol: soluble. SMILES: CC(C)/C=C/CCCCC(NCC1=CC(OC([2H])([2H])[2H])=C(C=C1)O)=O. InChi Code: InChI=1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+/i3D3. InChi Key: YKPUWZUDDOIDPM-HPFTVYJYSA-N. Origin: Synthetic.