C24:1 3'-sulfo Galactosylceramide (d18:1/24:1(15Z))

C24:1 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is the predominate sulfatide species in mature myelin, and it accumulates at a higher rate than C24 3'-sulfo galactosylceramide (Cay-24351) in rat cerebellum from seven to 32 days of age when active myelination occurs. It interacts with C-type lectins and immunoglobulin-like receptors with the highest affinity for LMIR5. It induces production of MCP-1 in basophils but not mast cells and increases the activation of NFAT in a reporter assay via LMIR5. C24:1 3'-sulfo Galactosylceramide is an immunodominant species in myelin, is bound by CD1d in vitro, and increases proliferation in isolated mouse splenocytes. It reduces symptoms and increases survival in a mouse model of chronic relapsing-remitting experimental autoimmune encephalomyelitis (EAE) when used at a dose of 20 µg. It also decreases the number of inflammatory lesions and infiltrating mononuclear cells in the lumbar spinal cord of EAE mice. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1931]Formal Name: N-[(1S)-2R-hydroxy-1-[[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl]-3E-heptadecen-1-yl]-15Z-tetracosenamide. CAS Number: 151057-28-2. Synonyms: (3'-sulfo)Galbeta-Cer(d18:1/24:1), N-Nervonoyl Sulfatide, C24:1 Sulfatide, cis-Tetracosenoyl Sulfatide, N-Tetracosenoyl (cis-15) Sulfatide. Molecular Formula: C48H91NO11S. Formula Weight: 890.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (5:1): soluble. SMILES: O[C@@H]1[C@@H](OS(O)(=O)=O)[C@@H](O)[C@@H](CO)O[C@H]1OC[C@H](NC(CCCCCCCCCCCCC/C=C\CCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C48H91NO11S/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-26-28-30-32-34-36-38-44(52)49-41(42(51)37-35-33-31-29-27-25-16-14-12-10-8-6-4-2)40-58-48-46(54)47(60-61(55,56)57)45(53)43(39-50)59-48/h17-18,35,37,41-43,45-48,50-51,53-54H,3-16,19-34,36,38-40H2,1-2H3,(H,49,52)(H,55,56,57)/b18-17-,37-35+/t41-,42+,43+,45-,46+,47-,48+/m0/s1. InChi Key: ZZQWQNAZXFNSEP-JCOQVFCVSA-N.