C18 Phytoceramide (t18:0/18:0)

C18 Phytoceramide (t18:0/18:0) (Cer(t18:0/18:0)) is a bioactive sphingolipid found in S. cerevisiae, wheat grains, and the stratum corneum layer of mammalian epidermis. Cer(t18:0/18:0) is composed of a phytosphingosine (Cay-20217) backbone amine-linked to a C18 fatty acid chain. Cer(t18:0/18:0) has a role in regulation of apoptosis, cell differentiation, proliferation of smooth muscle cells, and inhibition of the mitochondrial respiratory chain. It also inhibits expression of the allergic cytokines IL-4, TNF-alpha, and transcription factors c-Jun and NF-kappaB in histone-stimulated murine skin tissue. Formulations containing cer(t18:0/18:0) have been used used in cosmetics as a skin protectants as they reduce water loss to prevent epidermal dehydration and irritation. [Matreya, LLC. Catalog No. 2034]Formal Name: N-[(1S,2S,3R)-2,3-dihydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide. CAS Number: 34354-88-6. Synonyms: Cer(t18:0/18:0), Ceramide (t18:0/18:0), N-Octadecanoyl Phytosphingosine, C18:0 Phytoceramide, SPS, N-Stearoyl Phytosphingosine. Molecular Formula: C36H73NO4. Formula Weight: 584.0. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (1:1): Soluble (warmed). SMILES: OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@@H]([C@@H](CCCCCCCCCCCCCC)O)O. InChi Code: InChI=1S/C36H73NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-35(40)37-33(32-38)36(41)34(39)30-28-26-24-22-20-16-14-12-10-8-6-4-2/h33-34,36,38-39,41H,3-32H2,1-2H3,(H,37,40)/t33-,34+,36-/m0/s1. InChi Key: IEZRNEGTKRQRFV-LFBNJJMOSA-N.