C18 Ganglioside GD3-d3 (ammonium salt)

C18 Ganglioside GD3-d3 is intended for use as an internal standard in the quantification of ganglioside GD3 (Cay-17481) by GC- or LC-MS. Ganglioside GD3 is synthesized by the addition of two sialic acid residues to lactosylceramide (Cay-16983) and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. With roles in cell proliferation and differentiation, its expression increases during development and in pathological conditions such as cancer. Furthermore, the intracellular accumulation of ganglioside GD3 can contribute to mitochondrial damage, a crucial event during apoptosis. Ganglioside GD3 has become a target for therapeutic approaches to prevent malignant properties of tumor cells like melanoma. As this product is derived from a natural source, there may also be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 2054]Formal Name: N-[(1S,2R,3E)-1-[[[O-(N-acetyl-alpha-neuraminosyl)-(2->8)-O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]oxy]methyl]-2-hydroxy-3-heptadecen-1-yl]-octadecanamide-18,18,18-d3, diammonium salt. CAS Number: 2692624-24-9. Synonyms: Disialosyllactosylceramide-d3, N-omega-CD3-Octadecanoyl Disialoganglioside GD3 -d3. Molecular Formula: C70H120D3N3O29 . 2NH4. Formula Weight: 1509.8. Purity: >99% deuterated forms (d1 -d3). Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol:Water (2:1:0.1): Soluble. SMILES: OC[C@H]1O[C@@H](OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC)[C@H](O)[C@@H](O)[C@@H]1O[C@]2([H])O[C@H](CO)[C@H](O)[C@H](O[C@@]3(C([O-])=O)O[C@@H]([C@H](O)[C@H](O[C@@]4(C([O-])=O)O[C@@H]([C@H](O)[C@@H](CO)O)[C@H](NC(C)=O)[C@@H](O)C4)CO)[C@H](NC(C)=O)[C@@H](O)C3)[C@H]2O.[NH4+].[NH4+]. InChi Code: InChI=1S/C70H125N3O29.2H3N/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(84)73-44(45(80)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-95-65-59(89)58(88)61(51(40-77)97-65)98-66-60(90)64(56(86)49(38-75)96-66)102-70(68(93)94)36-47(82)54(72-43(4)79)63(101-70)57(87)50(39-76)99-69(67(91)92)35-46(81)53(71-42(3)78)62(100-69)55(85)48(83)37-74,,/h31,33,44-51,53-66,74-77,80-83,85-90H,5-30,32,34-41H2,1-4H3,(H,71,78)(H,72,79)(H,73,84)(H,91,92)(H,93,94),2*1H3/b33-31+,,/t44-,45+,46-,47-,48+,49+,50+,51+,53+,54+,55+,56-,57+,58+,59+,60+,61+,62+,63+,64-,65+,66-,69+,70-,,/m0../s1/i1D3,,. InChi Key: VFVCOMSDNRUTEK-MRGKXOJUSA-N.