C18 dihydro Ceramide (d18:0/18:0)

C18 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C18 ceramide (Cay-19556) that lacks the 4,5-trans double bond. Increased C18 dihydroceramide lipid levels lead to increased triacylglycerol storage and autophagosome accumulation as well as upregulation of the fibrosis markers alpha-SMA and FGF2 in Chang and LX-2 liver cells. C18 dihydro Ceramide is elevated in the plasma of pre-diabetics up to 9 years prior to the onset of type 2 diabetes. It is also elevated in the skin of patients with lesional atopic dermatitis.Formal Name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-octadecanamide. CAS Number: 2304-80-5. Synonyms: Cer(d18:0/18:0), Ceramide (d18:0/18:0), C18 Dihydroceramide, N-octadecanoyl-D-erythro-Dihydrosphingosine, N-Stearoylsphinganine. Molecular Formula: C36H73NO3. Formula Weight: 568.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMSO: Soluble, Ethanol: Warmed. SMILES: O=C(CCCCCCCCCCCCCCCCC)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC. InChi Code: InChI=1S/C36H73NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h34-35,38-39H,3-33H2,1-2H3,(H,37,40)/t34-,35+/m0/s1. InChi Key: KZTJQXAANJHSCE-OIDHKYIRSA-N.