C18 Ceramide-d3 (d18:1/18:0-d3)

C18 Ceramide-d3 (d18:1/18:0) is intended for use as an internal standard for the quantification of C18 Ceramide (d18:1/18:0) (Cay-19556) by GC- or LC-MS. C18 Ceramide is an endogenous bioactive sphingolipid. It is the primary short-chain ceramide found in brain tissue whose synthesis is regulated by longevity-assurance homologue 1 (Lass1) in mice. Increased expression of C18 ceramide reduces cell growth in UM-SCC-22A squamous cell carcinoma cells. It is selectively downregulated in 32 human head and neck squamous cell carcinoma tumor tissues as compared to non-squamous tumor tissues. C18 Ceramide concentration is significantly higher in muscle tissue of type 2 diabetic patients compared with non-diabetic patients and is positively correlated to body mass index and inversely related to insulin sensitivity. [Matreya, LLC. Catalog No. 2201]Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl-d3]-octadecanamide. CAS Number: 2011762-82-4. Synonyms: C18 Ceramide-d3, Cer(d18:1/18:0)-d3, Ceramide-d3 (d18:1/18:0-d3). Molecular Formula: C36H68D3NO3. Formula Weight: 569.0. Purity: >99% deuterated forms (d1-d3), =1% d0. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Soluble, DMF: Soluble, Ethanol: Warmed. SMILES: OC[C@H](NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C36H71NO3/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-36(40)37-34(33-38)35(39)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2/h29,31,34-35,38-39H,3-28,30,32-33H2,1-2H3,(H,37,40)/b31-29+/t34-,35+/m0/s1/i1D3. InChi Key: VODZWWMEJITOND-MOZMBTNASA-N.