C18 3'-sulfo Galactosylceramide (d18:1/18:0)

C18 3'-sulfo Galactosylceramide is a member of the sulfatide class of glycolipids. It is a minor endogenous sphingolipid produced from C18 ceramide (Cay-19556) and UDP-galactose in the endoplasmic reticulum followed by sulfation in the Golgi apparatus. C18 3'-sulfo Galactosylceramide levels are increased in brain tissue isolated from mice with an arylsulfatase A deficiency (ASA-KO), particularly in lipid raft fractions. Plasma levels of C18 3'-sulfo galactosylceramide positively correlate with disability progression in patients with relapsing-remitting multiple sclerosis using the Expanded Disability Status Scale. It is also increased in plasma from patients with metachromatic leukodystrophy (MLD). Brain levels of short-chain sulfatides, including C18 3'-sulfo galactosylceramide, decrease with age in mice and humans. As this product is derived from a natural source, there may be variations in the sphingoid backbone. [Matreya, LLC. Catalog No. 1932]Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-[[(3-O-sulfo-beta-D-galactopyranosyl)oxy]methyl]-3-heptadecen-1-yl]-octadecanamide. CAS Number: 244215-65-4. Synonyms: 3'-sulfo Galactosylceramide (d18:1/18:0), (3'-sulfo)Galbeta-Cer(d18:1/18:0), N-Octadecanoyl Sulfatide, C18 Sulfatide. Molecular Formula: C42H81NO11S. Formula Weight: 808.2. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (5:1): soluble. SMILES: O[C@@H]1[C@@H](OS(O)(=O)=O)[C@@H](O)[C@@H](CO)O[C@H]1OC[C@H](NC(CCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C42H81NO11S/c1-3-5-7-9-11-13-15-17-18-20-22-24-26-28-30-32-38(46)43-35(36(45)31-29-27-25-23-21-19-16-14-12-10-8-6-4-2)34-52-42-40(48)41(54-55(49,50)51)39(47)37(33-44)53-42/h29,31,35-37,39-42,44-45,47-48H,3-28,30,32-34H2,1-2H3,(H,43,46)(H,49,50,51)/b31-29+/t35-,36+,37+,39-,40+,41-,42+/m0/s1. InChi Key: GQQZXRPXBDJABR-BDZNYNMQSA-N.