C16 dihydro Ceramide (d18:0/16:0)

C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) (Cay-10681) that lacks the 4,5-trans double bond. C16 dihydro Ceramide (46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome c oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability to induce apoptosis, cytochrome c release, or channel formation in phospholipid membranes in the absence of C16 ceramide. [Matreya, LLC. Catalog No. 2078]Formal Name: N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]-hexadecanamide. CAS Number: 5966-29-0. Synonyms: Cer(d18:0/16:0), Ceramide (d18:0/16:0), N-hexadecanoyl-D-erythro-Dihydrosphingosine, N-Palmitoyl Sphinganine. Molecular Formula: C34H69NO3. Formula Weight: 539.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform:Methanol (5:1): Soluble, DMSO: Soluble, Ethanol: Soluble. SMILES: O=C(CCCCCCCCCCCCCCC)N[C@@H](CO)[C@H](O)CCCCCCCCCCCCCCC. InChi Code: InChI=1S/C34H69NO3/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-33(37)32(31-36)35-34(38)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h32-33,36-37H,3-31H2,1-2H3,(H,35,38)/t32-,33+/m0/s1. InChi Key: GCGTXOVNNFGTPQ-JHOUSYSJSA-N.