C14-O2

C14-O2 is an ionizable cationic lipid (apparent pKa = 6.6) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vitro and in vivo. LNPs containing C14-O2 and encapsulating mRNA encoding chimeric antigen receptor (CAR) induce CAR expression and B cell aplasia in mice.CAS Number: 2639634-77-6. Molecular Formula: C88H181N5O9. Formula Weight: 1453.4. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml, PBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml. SMILES: OC(CCCCCCCCCCCC)CN(CCN1CCN(CCOCCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC1)CCOCCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC. InChi Code: InChI=1S/C88H181N5O9/c1-6-11-16-21-26-31-36-41-46-51-56-84(94)79-91(68-72-100-76-78-102-74-70-93(82-87(97)59-54-49-44-39-34-29-24-19-14-9-4)83-88(98)60-55-50-45-40-35-30-25-20-15-10-5)66-65-89-61-63-90(64-62-89)67-71-99-75-77-101-73-69-92(80-85(95)57-52-47-42-37-32-27-22-17-12-7-2)81-86(96)58-53-48-43-38-33-28-23-18-13-8-3/h84-88,94-98H,6-83H2,1-5H3. InChi Key: HNVKEBOMDXBEIN-UHFFFAOYSA-N.