C14-4

C14-4 is an ionizable cationic lipid (pKa = 6.5). It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA. LNPs containing C14-4 and encapsulating mRNA encoding chimeric antigen receptor (CAR) induce CAR expression in primary human T cells ex vivo to the same level as expression induced via electroporation, but with reduced cytotoxicity, and induce cytotoxicity in Nalm-6 acute lymphoblastic leukemia (ALL) cells in vitro.Formal Name: 1,1'-[[2-[2-[4-[2-[[2-[2-[bis(2-hydroxytetradecyl)amino]ethoxy]ethyl](2-hydroxytetradecyl)amino]ethyl]-1-piperazinyl]ethoxy]ethyl]imino]bis-2-tetradecanol. CAS Number: 2639634-80-1. Synonyms: C14-494, Lipid B4. Molecular Formula: C84H173N5O7. Formula Weight: 1365.3. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solution in ethanol. Solubility: Ethanol: 10 mg/ml. SMILES: CCCCCCCCCCCCC(O)CN(CC(O)CCCCCCCCCCCC)CCOCCN(CCN1CCN(CCOCCN(CC(O)CCCCCCCCCCCC)CC(O)CCCCCCCCCCCC)CC1)CC(O)CCCCCCCCCCCC. InChi Code: InChI=1S/C84H173N5O7/c1-6-11-16-21-26-31-36-41-46-51-56-80(90)75-87(68-72-96-74-70-89(78-83(93)59-54-49-44-39-34-29-24-19-14-9-4)79-84(94)60-55-50-45-40-35-30-25-20-15-10-5)66-65-85-61-63-86(64-62-85)67-71-95-73-69-88(76-81(91)57-52-47-42-37-32-27-22-17-12-7-2)77-82(92)58-53-48-43-38-33-28-23-18-13-8-3/h80-84,90-94H,6-79H2,1-5H3. InChi Key: OQALBVGFAKJDAR-UHFFFAOYSA-N.