C10-200

C10-200 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA in vivo. LNPs containing C10-200 and encapsulating mRNA encoding a luciferase reporter selectively induce luminescence in the livers of mice to a greater extent than LNPs containing the branched-chain ionizable cationic lipidoid C12-200 (Cay-36699). LNPs containing C10-200 and encapsulating mRNA encoding erythropoietin (EPO) increase serum levels of EPO in mice.Formal Name: 1,1'-((2-(4-(2-((2-(bis(2-hydroxydecyl)amino)ethyl)(2-hydroxydecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(decan-2-ol). Molecular Formula: C60H125N5O5. Formula Weight: 996.7. Purity: >95% (mixture of isomers). Formulation: (Request formulation change), A solution in ethanol. Solubility: Chloroform: Sparingly soluble: 1-10 mg/ml, Ethanol: Soluble: >10 mg/mL. SMILES: OC(CCCCCCCC)CN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CCN1CCN(CCN(CC(CCCCCCCC)O)CC(CCCCCCCC)O)CC1. InChi Code: InChI=1S/C60H125N5O5/c1-6-11-16-21-26-31-36-56(66)51-63(48-50-65(54-59(69)39-34-29-24-19-14-9-4)55-60(70)40-35-30-25-20-15-10-5)47-45-61-41-43-62(44-42-61)46-49-64(52-57(67)37-32-27-22-17-12-7-2)53-58(68)38-33-28-23-18-13-8-3/h56-60,66-70H,6-55H2,1-5H3. InChi Key: BLPKMPWPNQWRQP-UHFFFAOYSA-N.