Butyric Acid-d7

Butyric acid-d7 is intended for use as an internal standard for the quantification of sodium butyrate (Cay-13121) by GC- or LC-MS. Butyric acid is a short-chain fatty acid. It is produced predominately by bacterial fermentation of dietary fiber in the colon but has also been identified in mammalian milk. Butyric acid is an inhibitor of histone deacetylase (HDAC, IC50 = 90 µM in a cell-free assay). It induces differentiation, cell cycle arrest at the G0 phase, and apoptosis, as well as inhibits proliferation, in a variety of cancer cells when used at concentrations ranging from 0.6 to 100 mM. Butyric acid decreases the expression of IFN-gamma-related signaling genes and metastatic genes in H460 human lung cancer cells when used at a concentration of 2 mM. It reduces tumor growth in a CaSki mouse xenograft model when administered at doses of 200 and 800 mg/kg per day. Butyric acid also reduces increases in colonic TNFa and Il6 expression and decreases colonic goblet cell depletion, tissue damage, muscle thickening, and cellular infiltration in a wild-type, but not Hcar2-/-, mouse model of TNBS-induced colitis.CAS Number: 73607-83-7. Synonyms: FA 4:0-d7. Molecular Formula: C4HD7O2. Formula Weight: 95.1. Purity: >98% deuterated forms (d1-d7). Formulation: (Request formulation change), A liquid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)/i1D3,2D2,3D2. InChi Key: FERIUCNNQQJTOY-NCKGIQLSSA-N.