Brassicasterol

Brassicasterol is a phytosterol found in canola and rapeseed oils, marine algae, and shellfish. It inhibits recombinant sterol Delta24-reductase with a Ki value of 42.7 µM in vitro. Brassicasterol increases accumulation of desmosterol, a cholesterol precursor and substrate of sterol Delta24-reductase, and inhibits cholesterol formation in HL-60 cells in a dose-dependent manner. It also inhibits the hemolytic activity of pneumolysin from S. pneumoniae without affecting bacterial growth at concentrations up to 1,000 µg/ml.Formal Name: ergosta-5,22E-dien-3beta-ol. CAS Number: 474-67-9. Molecular Formula: C28H46O. Formula Weight: 398.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 1 mg/ml, DMSO: 0.1 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. SMILES: CC(C)[C@@H](C)/C=C/[C@@H](C)[C@@]1([H])CC[C@@]2([H])C3=CC=C4C[C@@H](O)CC[C@]4(C)C3=CC[C@@]21C. InChi Code: InChI=1S/C28H42O/c1-18(2)19(3)7-8-20(4)24-11-12-25-23-10-9-21-17-22(29)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-10,14,18-20,22,24-25,29H,11-13,15-17H2,1-6H3/b8-7+/t19-,20+,22-,24+,25-,27-,28+/m0/s1. InChi Key: QSVJYFLQYMVBDR-CMNOFMQQSA-N.