Bicyclo Prostaglandin E2

Bicyclo prostaglandin E2 (Bicyclo PGE2) is a stable breakdown product of PGE2 (Cay-14010) and 13,14-dihydro-15-keto PGE2 (Cay-14650). Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE2 found in human plasma at a median level of 20-25 pg/ml. Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify it as bicyclo PGE2 to estimate PGE2 biosynthesis or metabolism in vivo.Formal Name: (5Z)-7-[(1R,3aS,7aS)-4-butyloctahydro-2,5-dioxo-1H-inden-1-yl]-5-heptenoic acid. CAS Number: 109826-53-1. Synonyms: Bicyclo PGE2. Molecular Formula: C20H30O4. Formula Weight: 334.5. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: >25 mg/ml, DMSO: >25 mg/ml, Ethanol: >30 mg/ml, PBS (pH 7.2): >1.4 mg/ml. SMILES: CCCCC1([H])C(CC[C@H]([C@H]2C/C=C\CCCC(O)=O)[C@@H]1CC2=O)=O. InChi Code: InChI=1S/C20H30O4/c1-2-3-8-16-17-13-19(22)15(14(17)11-12-18(16)21)9-6-4-5-7-10-20(23)24/h4,6,14-17H,2-3,5,7-13H2,1H3,(H,23,24)/b6-4-/t14-,15-,16?,17+/m1/s1. InChi Key: CGCZPIJMGKLVTQ-PAJBVNRRSA-N.