beta-Cortolone

beta-Cortolone is a metabolite of the glucocorticoid cortisol (hydrocortisone, Cay-20739). It is formed from cortisol by 20beta-hydroxysteroid dehydrogenase (20beta-HSD) via a 5beta-tetrahydrocortisol (Cay-34195) intermediate. Urinary levels of beta-cortolone are decreased in postmenopausal women with endometrial adenocarcinoma compared to postmenopausal women without endometrial adenocarcinoma.Formal Name: (5beta)-3alpha,17,20R,21-tetrahydroxy-pregnan-11-one. CAS Number: 667-66-3. Synonyms: 20beta-Cortolone, NSC 56997. Molecular Formula: C21H34O5. Formula Weight: 366.5. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: Slightly soluble (warmed), Methanol: Slightly soluble (warmed). SMILES: C[C@@]12[C@](CC[C@]2(O)[C@@H](CO)O)([H])[C@@]3([H])[C@@](C(C1)=O)([H])[C@@]4([C@](C[C@@H](CC4)O)([H])CC3)C. InChi Code: InChI=1S/C21H34O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12-15,17-18,22-23,25-26H,3-11H2,1-2H3/t12-,13-,14+,15+,17-,18-,19+,20+,21+/m1/s1. InChi Key: JXCOSKURGJMQSG-AIEJOZITSA-N.