Berbamine (hydrochloride)

Berbamine is a bisbenzylisoquinoline alkaloid that has been found in B. aristata and has diverse biological activities. It induces apoptosis and autophagy in, and is cytotoxic to, HT-29 cells when used at concentrations ranging from 3 to 100 µM. Berbamine reduces viral infectivity in Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, IC50 = 2.35 µM) and decreases cell surface levels of angiotensin-converting enzyme 2 (ACE2) in Huh7 cells when used at a concentration of 10 µM. In vivo, berbamine (25 and 50 mg/kg) reduces hepatic lipid accumulation and inflammatory cytokine levels, serum and hepatic triglyceride and total cholesterol levels, and serum aspartate aminotransferase (AST) and alanine transaminase (ALT) levels in a mouse model of ethanol-induced liver injury. It also protects against myocardial apoptosis, mitochondrial dysfunction, and lipid peroxidation in a rat model of myocardial infarction induced by isoproterenol (Cay-15592).Formal Name: 3,4,4aS,5,16aR,17,18,19-octahydro-21,22,26-trimethoxy-4,17-dimethyl-16H-1,24:6,9-dietheno-11,15-metheno-2H-pyrido[2',3':17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinolin-12-ol, dihydrochloride. CAS Number: 6078-17-7. Molecular Formula: C37H40N2O6 . 2HCl. Formula Weight: 681.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 12 mg/mL, DMSO: 12 mg/mL, Ethanol: Slightly soluble, PBS (pH 7.2): 0.25 mg/mL. SMILES: COC1=C2C3=C(CCN([C@]3([H])CC4=CC=C(O)C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)C)C=C1OC.Cl.Cl. InChi Code: InChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33,,/h6-11,18-21,28-29,40H,12-17H2,1-5H3,2*1H/t28-,29+,,/m0../s1. InChi Key: USRXDYNDPPUBSG-KKXMJGKMSA-N. Origin: Plant/Berberis julianae.