BAMEA-O16B

BAMEA-O16B is a disulfide bond-containing ionizable cationic lipid. It has been used in the generation of lipid nanoparticles (LNPs) for the delivery of CRISPR complementary single-guide RNA (sgRNA) and Cas9 mRNA for genome editing in vitro and in vivo. LNPs containing BAMEA-O16B encapsulating Cas9 mRNA and sgRNAs targeting the gene encoding proprotein convertase subtilisin kexin type 9 (PCSK9) accumulate in the liver and decrease serum PCSK9 levels in mice.Formal Name: bis(2-(dodecyldisulfaneyl)ethyl) 3,3'-((3-methyl-9-oxo-10-oxa-13,14-dithia-3,6-diazahexacosyl)azanediyl)dipropionate. CAS Number: 2490668-30-7. Synonyms: BAMPA-O16B. Molecular Formula: C56H111N3O6S6. Formula Weight: 1114.9. Purity: >95%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: Ethanol: Soluble. SMILES: O=C(CCNCCN(CCN(CCC(OCCSSCCCCCCCCCCCC)=O)CCC(OCCSSCCCCCCCCCCCC)=O)C)OCCSSCCCCCCCCCCCC. InChi Code: InChI=1S/C56H111N3O6S6/c1-5-8-11-14-17-20-23-26-29-32-48-66-69-51-45-63-54(60)35-38-57-39-42-58(4)43-44-59(40-36-55(61)64-46-52-70-67-49-33-30-27-24-21-18-15-12-9-6-2)41-37-56(62)65-47-53-71-68-50-34-31-28-25-22-19-16-13-10-7-3/h57H,5-53H2,1-4H3. InChi Key: WBCDKXLTOZQTMM-UHFFFAOYSA-N.